The Collaborative Research Centre/Transregio CRC/TRR 225 “From the Fundamentals of Biofabrication towards Functional Tissue Models” is an interdisciplinary research consortium of the Universities of Würzburg, Bayreuth, and Erlangen-Nürnberg.
The TRR225 aims to develop innovative biofabrication strategies - particularly automated 3D printing technologies - for processing living cells and biomaterials into complex tissue constructs. These advanced in vitro models provide new opportunities for pharmaceutical, cancer, and infection research, support the reduction of animal testing and offer long-term perspectives for regenerative medicine.
Since its establishment in 2018, the consortium has achieved substantial scientific progress and international visibility and will enter its third funding period in 2026.
The advertised position is part of the subproject C07 Endothelialized perfusable microvascular networks for biofabrication of standardized in vitro tissue models, which focuses on Vascularization as a key challenge in the biofabrication of hierarchical tissue structures and their application. In detail, we aim to fabricate perfusable endothelialized microvascular networks mimicking the peripheral vessels and the blood-brain barrier. These will serve as a basis for functional, tissue-specific investigations in health and disease. Building on previous knowledge and methods, free-form printing of POx will be used to increase the complexity of sacrificial structures and incorporate functional, stable vessel-like structures into complex 3D tissue models. The developed models should better reflect physiological conditions and improve predictive power in preclinical testing.
For more information, please see this document and https://trr225biofab.de/project-c07/
Contact
For inquiries or to submit your application, please contact the person below. Please submit your documents by December 31, 2025.
Dr. Antje Appelt-Menzel and Dr. Matthias Ryma
University Hospital Würzburg / Department for Functional Materials in Medicine and Dentistry / Project C07
+49 931 31-80771